Kelly Rome

This study shows that BCAAs are sensed differently by mTOR and c-Myc in T cells, governing proliferation independently of catabolism.

This study shows that histone propionylation, influenced by nutrient availability, regulates T cell fate and antitumor immunity.

This study shows glucose availability independently regulates CD8+ T cell expansion potential through mTOR-dependent mechanisms, distinct from mitogenic signals.

This study shows that malnutrition impairs immune function and myelopoiesis in mice, which partially recovers with refeeding but does not fully restore infection resistance.

This study shows CD8+ T cells adapt to nutrient stress by reconfiguring gene-regulatory and metabolic networks, enabling functional resilience and anti-tumor immunity.