Author

Tran Ngoc Van Le

Children's Hospital of PhiladelphiaORCID 0000-0002-0342-2634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Kelly RomeiD· 4 shared Will BailisiD· 4 shared Krittin TrihemasavaiD· 3 shared Aaron Wu· 2 shared Alison JaccardiD· 2 shared Elise Hall· 2 shared Kathryn E. WelleniD· 2 shared Lucien H. TurneriD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

Kelly RomeORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Distinct sensing of BCAAs by mTOR and c-Myc governs T cell proliferation, independent of catabolism

Kelly Rome, Elise Hall, Tran Ngoc Van Le, Alison Jaccard, Aaron Wu, Nathaniel W. Snyder, Kathryn E. Wellen, Will Bailis

This study shows that BCAAs are sensed differently by mTOR and c-Myc in T cells, governing proliferation independently of catabolism.

EMBO Reports · Oct 28, 2026Peer-reviewedImmunology

Nutrient-sensitive histone propionylation regulates T cell fate and function

Alison Jaccard, Kelly Rome, Qihua Yang, Shuo Zhang, Noah Ford, Adam G. Chatoff, Tran Ngoc Van Le, Michael Noji, Andrea Andress Huacachino, Stephanie Stransky, Carlos M. Pondevida, Krittin Trihemasava, Laura V. Pinheiro, Sanat Bhadsalve, Eun Kyung Ko, , Kathryn E. Wellen

This study shows that histone propionylation, influenced by nutrient availability, regulates T cell fate and antitumor immunity.

bioRxiv · Oct 6, 2026 · PreprintImmunology

Glucose availability tunes latent CD8+ T cell expansion potential through a mitogen-independent, mTOR-dependent regulatory switch

Tran Ngoc Van Le, Krittin Trihemasava, Lucien H. Turner, Kelly Rome, Aaron Wu, Will Bailis

This study shows glucose availability independently regulates CD8+ T cell expansion potential through mTOR-dependent mechanisms, distinct from mitogenic signals.

bioRxiv · Jan 17, 2026 · PreprintImmunology

Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stress

Michael Scaglione, Montana Knight, Krittin Trihemasava, Kelly Rome, Anne‐Sophie Archambault, Ju‐Hee Oh, Erin Tanaka, Elise Hall, Tran Ngoc Van Le, Caleb L. Lines, Brian P. Goldspiel, Hossein Fazelinia, Clémence Queriault, Lucien H. Turner, Tanay S. Parnaik, , Will Bailis

This study shows CD8+ T cells adapt to nutrient stress by reconfiguring gene-regulatory and metabolic networks, enabling functional resilience and anti-tumor immunity.

bioRxiv · Jan 22, 2025 · PreprintImmunology