Author

Michael Scaglione

Children's Hospital of PhiladelphiaORCID 0000-0003-2953-1748Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Crystal S. ConniD· 3 shared Will BailisiD· 3 shared Brian P. GoldspieliD· 2 shared Clémence QueriaultiD· 2 shared Clementina MesarosiD· 2 shared Hossein FazeliniaiD· 2 shared Lynn A. SpruceiD· 2 shared Montana KnightiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

Crystal S. ConnORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 1, 2026

SPTBN2 promotes an immunosuppressive tumor microenvironment and cross-resistance to anti-cancer therapies

Quoc Thang Bui, Raghavendra Basavaraja, Mayura R. Dhamdhere…·Serge Yu. Fuchs

This study identifies SPTBN2 as a regulator of immunosuppressive tumor microenvironment and cross-resistance to therapies, showing its role in suppressing CAR T-cell efficacy.

DOI 10.64898/2026.03.30.715365

humanmouse

𝕏 PostBluesky

ImmunologybioRxivPreprintJan 20, 2026

Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly

Mikel D. Haggadone, Brian P. Goldspiel, Aoife O’Farrell…·Will Bailis

This study shows that environmental branched-chain amino acids regulate ASC translation and NLRP3 inflammasome assembly through mTOR-dependent translational bursting.

1 citation

mousehuman

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ImmunologybioRxivPreprintJan 22, 2025

Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stress

Michael Scaglione, Montana Knight, Krittin Trihemasava…·Will Bailis

This study shows CD8+ T cells adapt to nutrient stress by reconfiguring gene-regulatory and metabolic networks, enabling functional resilience and anti-tumor immunity.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky