Spatiotemporal dynamics of Mcl-1 abundance and its influence on apoptosis susceptibility
Fabian Klötzer, Nadine Pollak, Anna Baatz, Batuhan Kısakol, Fiona Ginty, Daniel B. Longley, Jochen H.M. Prehn, Markus Rehm
This study shows Mcl-1 accumulation and redistribution during the cell cycle increase MOMP thresholds, contributing to cell-to-cell variability in apoptosis susceptibility and intra-tumour heterogeneity.
bioRxiv · Feb 9, 2026 · PreprintCell Biology