Author

Denis Ruchnewitz

University of CologneORCID 0000-0001-5740-6958Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:virus· 1

Frequent Co-Authors

Jan Eberhardt· 2 shared Marta ŁukszaiD· 2 shared Matthijs MeijersiD· 2 shared Michael LässigiD· 2 shared Alexander W. CharneyiD· 1 shared Andreas Pinger· 1 shared Ania WajnbergiD· 1 shared Anna KaminskaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

Jan Eberhardt

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Detection of low pre-existing humoral immunity against influenza virus H5N1 clade 2.3.4.4b in unexposed individuals

Katharina Daniel, Leon Ullrich, Denis Ruchnewitz, Matthijs Meijers, Nico Joël Halwe, Ursula Wild, Jan Eberhardt, Jacob Schön, Ricarda Stumpf, Maike Schlotz, Marie Wunsch, Luana Girao Lessa, Elsayed M. Abdelwhab, Maryna Kuryshko, Christopher Dietrich, , Florian Klein

The paper assesses pre-existing humoral immunity against H5N1 clade 2.3.4.4b in unexposed individuals and finds low but distinct cross-neutralizing titers.

Immunity · Jan 30, 2026Peer-reviewedImmunology

T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.

Cansu Cimen Bozkus, Matthew Brown, Leandra G. Velazquez, Marcus Thomas, Eric A. Wilson, Timothy J. O’Donnell, Anna Kaminska, Denis Ruchnewitz, Douglas Geertz, Yonina Bykov, Julia Kodysh, Kasopefoluwa Y. Oguntuyo, Vladimir Roudko, David Hoyos, Komal Srivastava, , Nina Bhardwaj

The paper maps T cell epitopes in SARS-CoV-2, showing that immunodominant regions are conserved across variants and important for immune surveillance.

iScience · Jul 2, 2025Peer-reviewedImmunology

Concepts and methods for predicting viral evolution

Matthijs Meijers, Denis Ruchnewitz, Jan Eberhardt, Malancha Karmakar, Marta Łuksza, Michael Lässig

This paper develops methods to predict viral evolution using integrated data on sequences, epidemiology, antigenicity, and phenotypes, providing vaccine strain selection insights.

bioRxiv · Mar 19, 2024 · PreprintBiophysics