The paper develops a platform for producing functionalised PHA nanoparticles using C. necator, demonstrating customisable material properties and bioprocess improvements.

bioRxiv · Mar 18, 2026 · PreprintSynthetic Biology

Establishing Vibrio natriegens as a high-performance host for acetate-based poly-3-hydroxybutyrate production

Roland J Politan, Simona Della Valle, Luke Pineda, Jitendra Joshi, Christian Euler, Gavin R. Flematti, Georg Fritz

This study enhances Vibrio natriegens' ability to produce poly-3-hydroxybutyrate from acetate through adaptive evolution and metabolic engineering, achieving high productivity and biomass accumulation.

Metabolic Engineering · Jul 15, 2025Peer-reviewedSynthetic Biology

Streamlined and efficient genome editing in Cupriavidus necator H16 using an optimised SIBR-Cas system

Simona Della Valle, Enrico Orsi, Sjoerd C.A. Creutzburg, Luc F.M. Jansen, Evangelia-Niki Pentari, Chase L. Beisel, Harrison Steel, Pablo I. Nikel, Raymond H.J. Staals, Nico J. Claassens, John van der OOST, Wei E. Huang, Constantinos Patinios

This study optimizes a genome editing system for Cupriavidus necator H16, achieving high editing efficiency using an improved SIBR-Cas system.

Trends in biotechnology · Mar 13, 2025Peer-reviewedBioengineering

Neuronal perception of the social environment intergenerationally controls germline development and generation time in C. elegans

Marcos Francisco Perez, Mehrnaz Shamalnasab, Alejandro Mata‐Cabana, Simona Della Valle, María Olmedo, Mirko Francesconi, Ben Lehner

The paper shows that neuronal perception of social pheromones in C. elegans affects germline development timing and generation time in offspring.

Current Biology · Aug 5, 2021Peer-reviewedGenetics