Marcos Francisco Perez

The paper creates a cellular atlas of gene expression in fed and starved C. elegans L1 larvae, revealing transcription in starved primordial germ cells and the role of aak-1/AMPK in chromatin compaction.

The paper assesses PTEN variant functionality across species, showing context-dependent oncogenicity and interindividual variability using C. elegans and cell lines.

CelEsT estimates TF activities in C. elegans using a unified GRN, validated across multiple datasets and conditions.

The paper investigates the metabolic role of histone methylation in human cells using metabolomics, proteomics, and RNA-seq data, finding that histone methyltransferases are co-regulated by Rb and linked to SAM homeostasis.

The paper shows that chromatin state changes occur spontaneously in C. elegans and can lead to heritable gene expression variation.

The paper identifies that malignancy and NF-kB signalling enhance coordination between mitochondrial and nuclear-encoded oxidative phosphorylation genes in cancer, while healthy tissues show weak or inconsistent coordination.

The paper shows that neuronal perception of social pheromones in C. elegans affects germline development timing and generation time in offspring.