Author

Carl T. Ash

ORCID 0000-0002-0767-9605Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Jan-Hannes SchäferiD· 2 shared Jeffery W. KellyiD· 2 shared Robert T. O'Neill· 2 shared Benjamin F. CravattiD· 1 shared Daniel SerwasiD· 1 shared Daniella A. Yacoubian· 1 shared David A. AgardiD· 1 shared Elizabeth A. MontabanaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

Jan-Hannes SchäferORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Intralysosomal Amyloidogenesis and Proximity Labeling by Cathepsin C

Ruben D. Elias, Seth Allen, Idil Itir Demiralp, Robert T. O'Neill, Jan-Hannes Schäfer, Hannah Siems, Elizabeth A. Montabana, Utz H. Ermel, Carl T. Ash, Fatema Abdurrob, Daniella A. Yacoubian, Oren L. Lederberg, Daniel Serwas, David A. Agard, Benjamin F. Cravatt, Jeffery W. Kelly

This study identifies two mechanisms by which dipeptide esters disrupt lysosomal homeostasis: amyloid fibril formation and proximity labeling via Cathepsin C.

bioRxiv · Jul 7, 2026 · PreprintBiochemistry

3D Visualization and Proteomic Analysis of Human Cardiac Transthyretin Amyloidosis Tissue Reveals Microangiopathy and Capillary Occlusion

Joseph P. Donnelly, Jan-Hannes Schäfer, Leonard Yoon, Lynée A. Massey, Carl T. Ash, Zi Gao, Karina Nugroho, Marcus Jäger, Zhengyuan Pang, Robert T. O'Neill, Mathew S. Maurer, Evan T. Powers, Gabriel C. Lander, Ye Li, Jeffery W. Kelly

This study uses proteomics and 3D imaging to show that ATTR cardiac amyloidosis involves microangiopathy, capillary occlusion, and vascular basement membrane congestion.

bioRxiv · Feb 11, 2026 · PreprintPathology