Petra Beznosková

Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough

The paper shows that near-cognate tRNAs that promote stop codon readthrough form specific contacts with ribosomal proteins at the decoding site, with the anticodon stem length and structure influencing this interaction.

Stem-loop induced ribosome queuing in the uORF2/ATF4 overlap fine-tunes stress-induced human ATF4 translational control

The paper identifies a stem-loop and modified adenines in the uORF2/ATF4 overlap that regulate ATF4 translation under stress, revealing a more complex mechanism than previously thought.

Cysteine tRNA acts as a stop codon readthrough-inducing rti-tRNA in the human HEK293T cell line.

The paper investigates the readthrough-inducing potential of human tRNACys in HEK293T cells, finding that two isoacceptors can significantly elevate UGA readthrough.

eIF3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex

The paper investigates eIF3's roles in mRNA recruitment to the ribosomal preinitiation complex by analyzing functional variants in yeast, revealing distinct roles at entry and exit channels.