Author

Sergio Wittlin

Swiss Tropical and Public Health InstituteORCID 0000-0002-0811-0912Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Organism:plant (other)· 3 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

David Armand FidockiD· 3 shared Francisco‐Javier GamoiD· 2 shared Lyn‐Marié BirkholtziD· 2 shared Tomas YeoiD· 2 shared Alexandra E. GouldiD· 1 shared Angela HellingmaniD· 1 shared Anna Caroline Campos AguiariD· 1 shared Anna Y. Burkhard· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMicrobiology

David Armand FidockORCID

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintJul 28, 2026

Multidimensional in vitro assay for antimalarial combination testing and pharmacodynamic modeling - the MULT-i2 assay

Angela Hellingman, Christin Gumpp, Jörg J. Möhrle…·Matthias Rottmann

The paper introduces a high-throughput in vitro assay for evaluating antimalarial drug combinations and their pharmacodynamic interactions, showing improved efficiency and resolution compared to existing methods.

DOI 10.64898/2026.05.06.723157

plant (other)experimental assay

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MicrobiologyACS Chemical BiologyPeer-reviewedJun 13, 2026

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation

Kathryn J. Wicht, John G. Woodland, Larnelle F. Garnie…·Kelly Chibale

This study shows that CHIR-124, a human Chk1 inhibitor, is active against Plasmodium falciparum through dual inhibition of PfArk1 and hemozoin formation, suggesting polypharmacology as a strategy for antimalarial drugs.

5 citationstop 1%

humanmouse

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MicrobiologybioRxivPreprintApr 3, 2026

Double Mutations in Plasmodium falciparum Kelch13 drive resistance to next-generation artemisinin derivatives in malaria parasites

Christopher Bower-Lepts, Kurt E. Ward, Sergio Wittlin…·Sachel Mok

This study identifies a novel K13 double mutation conferring resistance to ozonide antimalarials in Plasmodium falciparum parasites with existing artemisinin resistance.

DOI 10.64898/2026.04.02.716214

plant (other)whole-genome sequencing

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BiochemistryPLoS PathogensPeer-reviewedDec 9, 2024

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo

Stanley C. Xie, Chia-Wei Tai, Craig J. Morton…·Leann M. Tilley

5 citations

plant (other)experimental assay

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