Author

Christopher Bower-Lepts

Aaron Diamond AIDS Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Sachel MokiD· 2 shared Abhai Tripathi· 1 shared Alejandro McCotter-Gonzalez· 1 shared Anne‐Catrin UhlemanniD· 1 shared Arvind Jangra· 1 shared Barbara H. StokesiD· 1 shared Cindy Smidt· 1 shared David A. FidockiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

Sachel MokORCID

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Author profile →

3 papers

Recent·Most cited

A Plasmodium falciparum PX1 haplotype is associated with reduced susceptibility to artemisinin and lumefantrine

Christopher Bower-Lepts, Arvind Jangra, Sachie Kanatani, Abhai Tripathi, Godfree Mlambo, Alejandro McCotter-Gonzalez, Linda Romano, Stephen Orena, Martin Okitwi, Karamoko Niaré, Philip Joseph Rosenthal, Melissa D. Conrad, Photini Sinnis, Sachel Mok

This study identifies a PX1 haplotype in Plasmodium falciparum associated with reduced susceptibility to artemisinin and lumefantrine, providing a marker for drug resistance surveillance.

bioRxiv · Sep 9, 2026 · PreprintMicrobiology

Double Mutations in Plasmodium falciparum Kelch13 drive resistance to next-generation artemisinin derivatives in malaria parasites

Christopher Bower-Lepts, Kurt E. Ward, Sergio Wittlin, Barbara H. Stokes, Tomas Yeo, Tarrick Qahash, Jennifer L. Small-Saunders, Heekuk Park, Anne‐Catrin Uhlemann, Manuel Llinás, David A. Fidock, Sachel Mok

This study identifies a novel K13 double mutation conferring resistance to ozonide antimalarials in Plasmodium falciparum parasites with existing artemisinin resistance.

bioRxiv · Apr 3, 2026 · PreprintMicrobiology

A novel chemogenomic screening platform for scalable antimalarial drug target identification

Christopher Bower-Lepts, Mukul Rawat, William Collins Keith, Gareth Girling, Madeline R. Luth, Krypton Carolino, Katharina Boroviak, Rachael Coyle, Frank Schwach, Cindy Smidt, Ellen Bushell, Sonia Moliner Cubel, Maria De Gracia Gomez-Lorenzo, Francisco‐Javier Gamo, Elizabeth A. Winzeler, , Julian C. Rayner

This paper develops a chemogenomic platform using Plasmodium berghei artificial chromosomes to identify antimalarial drug targets through barcode sequencing and validation in Plasmodium falciparum.

bioRxiv · Aug 27, 2024 · PreprintMicrobiology