Yasushi Saeki

Development of CRISPR/Cas13-based analytical tools to study RNA-Protein Interactions

The paper develops CRISPR/Cas13-based tools to analyze RNA-protein interactions by integrating existing PPI methods with RNA-targeting Cas13, demonstrating their utility in studying paraspeckles.

Caveolin-1 controls lineage fidelity of adult neural stem cells via lysosomal degradation of PDGFRα

This study shows that caveolin-1 maintains adult neural stem cell quiescence and lineage fidelity by promoting lysosomal degradation of PDGFRα.

Editing of the polyubiquitin architecture on the collided ribosome maintains persistent RQC activity

The paper identifies the roles of Ubp2 and Ubp3 in editing polyubiquitin chains on ribosomes to maintain RQC activity.

Intrinsic and TDP-43 dysfunction-induced catabolic stress elicit neuroprotective cellular degradation in ALS-vulnerable motor neurons

The paper identifies large spinal motor neurons as highly autophagic and shows that their enhanced degradation is neuroprotective in ALS.

Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome

This study shows that eS7A ubiquitination during ER stress in yeast regulates mRNA translation and affects stress outcomes.

α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome

The paper shows that different α-synuclein strains cause distinct pathologies by differentially inhibiting proteasome activity through structural differences in their C-terminal regions.

HERC2 promotes BLM and WRN to suppress G-quadruplex DNA

This study shows HERC2 promotes BLM and WRN to suppress G-quadruplex DNA, with E3 activity essential for this function and affecting cell sensitivity to G4 stabilizers.