Author

Marianna B. Ruzinova

Washington University in St. LouisORCID 0000-0002-0833-8335Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Brett L. KnolhoffiD· 1 shared Caroline Bonmati· 1 shared Clément Collignon· 1 shared Colin HercusiD· 1 shared Daniel A.C. Fisher· 1 shared Daniel C. LinkiD· 1 shared Daniel L.J. ThorekiD· 1 shared David G. DeNardoiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

Brett L. KnolhoffORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting Tumor-intrinsic TAK1 triggers anti-tumor immunity and sensitizes pancreatic cancer to checkpoint blockade

Sapana Bansod, Timothy Hung-Po Chen, Vikas Somani, Lin Li, Suneeta Modekurty, Brett L. Knolhoff, Ryan Courtney Fields, Marianna B. Ruzinova, David G. DeNardo, Kian‐Huat Lim

This study identifies TAK1 as a therapeutic target in pancreatic cancer that enhances anti-tumor immunity and sensitizes tumors to checkpoint blockade.

bioRxiv · Oct 8, 2025 · PreprintCancer Biology

Genomic and Immunogenomic Profiling of Extramedullary Acute Myeloid Leukemia Reveals Actionable Clonal Branching and Frequent Immune Editing

Clément Collignon, T H Hansen, Colin Hercus, Marianna B. Ruzinova, Gabrielle Roth Guépin, Caroline Bonmati, Marie‐Thérèse Rubio, Pierre Feugier, Mélanie Gaudfrin, Hervé Sartelet, Marion Divoux, Marc Müller, Sharon E. Heath, Geoffrey L. Uy, David H. Spencer, , Francesca Ferraro

This study profiles genomic and immunogenomic features of eAML, finding clonal branching and immune editing, with FLT3 mutations in relapsed cases.

Blood Cancer Journal · Aug 13, 2025Peer-reviewedGenomics

IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry

Peng Lu, Karolyn A. Oetjen, Diane E. Bender, Marianna B. Ruzinova, Daniel A.C. Fisher, Kevin G. Shim, Russell Kent Pachynski, William Nathaniel Brennen, Stephen T. Oh, Daniel C. Link, Daniel L.J. Thorek

IMC-Denoise improves Imaging Mass Cytometry image quality by reducing noise and artifacts, enhancing downstream analysis.

Nature Communications · Mar 23, 2023Peer-reviewedBioinformatics