Amy L. Hartman

Oropouche virus causes acute hepatitis in mice controlled by Type I interferons

This paper establishes two mouse models of Oropouche virus-induced hepatitis, showing that Type I interferons control disease severity and that contemporary isolates are less pathogenic than historical strains.

Characterization of neural infection by Oropouche orthobunyavirus

This study characterizes Oropouche orthobunyavirus replication in neural cells and brain slices, showing cytokine production and providing a model for studying viral neuropathogenesis.

Lrp1 facilitates infection of neurons by Jamestown Canyon virus

This study identifies Lrp1 as a host factor required for Jamestown Canyon virus infection of neurons and shows it is shared by other bunyaviruses.

Oropouche virus infects human placenta explants and trophoblast organoids

This study shows Oropouche virus infects human placenta tissues and trophoblast organoids, potentially causing adverse pregnancy outcomes through vertical transmission.

Vaccine strains of Rift Valley fever virus exhibit attenuation at the maternal-fetal placental interface

This study shows that vaccine strains of Rift Valley fever virus replicate less in placental tissues compared to wild-type strains, suggesting attenuation at the maternal-fetal interface.