Oropouche virus causes acute hepatitis in mice controlled by Type I interferons
Cade E. Sterling, Rachael E. Rush, Jackson J. McGaughey, Brian Snow, Alexandra J. Benton, William Paul Duprex, Gaya K. Amarasinghe, Satdarshan P. Monga, Amy L. Hartman
This paper establishes two mouse models of Oropouche virus-induced hepatitis, showing that Type I interferons control disease severity and that contemporary isolates are less pathogenic than historical strains.
Journal of Virology · Jun 30, 2026Peer-reviewedMicrobiology