Author

Xuemin Chen

National Cancer InstituteORCID 0000-0002-0860-4365Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jordan L. MeieriD· 2 shared Kiall F. SuazoiD· 2 shared Alexandra CastroverdeiD· 1 shared Anver Basha ShaikiD· 1 shared Benjamin Aaron GarciaiD· 1 shared Joycelyn H. Williams· 1 shared K. HuberiD· 1 shared Ludwig G. BaueriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Jordan L. MeierORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedMay 13, 2026

Hierarchical small molecule inhibition of MYST acetyltransferases

Xuemin Chen, Alexandra Castroverde, Minervo Perez…·Jordan L. Meier

This paper evaluates the potency and selectivity of MYST KAT inhibitors using chemoproteomic profiling and identifies new complex members, highlighting dose-dependent inhibition patterns and potential therapeutic applications.

2 citations

humanproteomics

𝕏 PostBluesky

BiochemistryJACS AuPeer-reviewedJul 29, 2024

Paralogue-selective degradation of the lysine acetyltransferase EP300

Xuemin Chen, McKenna C. Crawford, Ying Xiong…·Jordan L. Meier

This study develops a small molecule, MC-1, that selectively degrades EP300 over CREBBP, revealing factors governing paralogue-specific degradation and its impact on cancer cell proliferation.

12 citations

humanproteomics

𝕏 PostBluesky