Molecular Architecture of the Human GCN1-ABCF3 Ribosome Collision Sensor
Viswanathan Chandrasekaran, Ritu Gupta, Mary Talatu Angani, Talal F. M. Haddad, Christopher G. Tate, Venki Ramakrishnan, Alan G. Hinnebusch
This study identifies ABCF3 as the mammalian ortholog of yeast Gcn20, which is recruited to ribosomes during amino acid starvation and interacts with GCN1 to activate Gcn2.
bioRxiv · Sep 22, 2026 · PreprintBiochemistry