Venki Ramakrishnan

Molecular Architecture of the Human GCN1-ABCF3 Ribosome Collision Sensor

This study identifies ABCF3 as the mammalian ortholog of yeast Gcn20, which is recruited to ribosomes during amino acid starvation and interacts with GCN1 to activate Gcn2.

Molecular architecture and diversity of StopGo/2A translational recoding

The paper investigates the StopGo/2A translational recoding mechanism using cryo-EM and bioinformatics, revealing structural and sequence features that enable this process in viruses.

Mechanism of translation initiation on endogenous eukaryotic circular RNAs

This study investigates translation initiation mechanisms on endogenous eukaryotic circular RNAs, showing that initiation depends on UTRs and specific initiation factors.

Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in 40S small ribosomal subunit

This study determines the structure of Pdcd4 bound to the 40S ribosomal subunit, revealing its binding site and mechanism in translational control.

The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A

The paper describes the structure of a human 48S initiation complex, revealing a second eIF4A helicase at the mRNA entry site that unwinds secondary structure downstream of the scanning complex.