This study systematically reviews postmortem evidence of metabotropic glutamate receptor alterations across neuropsychiatric disorders, finding context-dependent changes rather than uniform molecular signatures.

bioRxiv · Sep 3, 2026 · PreprintNeuroscience

Dopamine shapes brain metastate dynamics

Daisuke Matsuyoshi, Yasuyuki Kimura, Keisuke Takahata, Yoko Ikoma, Chie SEKI, Ming-Rong Zhang, Makoto Higuchi, Tetsuya Suhara, Makiko Yamada

This study investigates how dopamine affects brain metastate dynamics using a combination of PET, fMRI, and hidden Markov modeling, finding that dopamine shifts the balance between internally oriented and sensorimotor-perceptual brain states.

bioRxiv · Jan 31, 2026 · PreprintNeuroscience

Remote Cortical Network for Frontal Cognitive Symptoms Derived from Tau Accumulation in Progressive Supranuclear Palsy

Yuki Hori, Hironobu Endo, Kenji Tagai, Yuko Kataoka, Ryoji Goto, Shin Kurose, Yuki Momota, Naomi Kokubo, Chie Seki, Sho Moriguchi, Hitoshi Shimada, Hitoshi Shinotoh, Takahiko Tokuda, Keisuke Takahata, Takafumi Minamimoto, , Toshiyuki Hirabayashi

This study identifies a cortical network linked to frontal cognitive symptoms in PSP through remote effects of tau deposits, independent of atrophy.

bioRxiv · Feb 5, 2025 · PreprintNeuroscience

Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases

Hironobu Endo, Maiko Ono, Yuhei Takado, Kiwamu Matsuoka, Manami Takahashi, Kenji Tagai, Yuko Kataoka, Kosei Hirata, Keisuke Takahata, Chie Seki, Naomi Kokubo, Masayuki Fujinaga, Wakana Mori, Yuji Nagai, Koki Mimura, , Makoto Higuchi

This study develops a PET ligand to visualize α-synuclein pathologies in Parkinson's and DLB patients, showing increased signals in affected brain regions.

Neuron · Jun 5, 2024Peer-reviewedNeuroscience

Serotonergic neural network related to behavioral inhibition system

Kazuho Kojima, Shigeki Hirano, Yasuyuki Kimura, Chie Seki, Yoko Ikoma, Keisuke Takahata, Takehito Ito, Keita Yokokawa, Hiroki Hashimoto, Kazunori Kawamura, Ming‐Rong Zhang, Hiroshi Ito, Makoto Higuchi, Satoshi Kuwabara, Tetsuya Suhara, Makiko Yamada

The paper investigates the relationship between behavioral inhibition system scores and 5-HT2A receptor availability in the anterior cingulate cortex, identifying a functional connectivity network involving the left middle frontal gyrus.

bioRxiv · Jul 9, 2021 · PreprintNeuroscience