Author

Makoto Higuchi

National Institutes for Quantum Science and TechnologyORCID 0000-0002-9190-7235Unclaimed ORCID profile · follow to get notified of new preprints

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Makoto Higuchi4 papers · National Institutes for Quantum Science and Technology

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:imaging· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Chie SekiiD· 3 shared Takafumi MinamimotoiD· 3 shared Hironobu EndoiD· 2 shared Hiroyuki TakuwaiD· 2 shared Hitoshi ShimadaiD· 2 shared Hitoshi ShinotohiD· 2 shared Keisuke TakahataiD· 2 shared Kenji TagaiiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Chie SekiORCID

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3 papers

Recent·Most cited

Pharmacological potentiation of Nav1.1 channels in interneurons mitigates tau depositions and neuronal death in a mouse model of neurodegenerative dementias

Kazuaki Sampei, Junya Hirokawa, Takehiro Kudo, Chie Seki, Hiroyuki Takuwa, Jun Maeda, Maiko Ono, Masaki Tokunaga, Nobuhiro Nitta, Shigeyuki Honda, Taeko Kimura, Yumi Matsushita, Taizo Ishikawa, Yuhei Takado, Ming‐Rong Zhang, , Masafumi Shimojo

bioRxiv · Aug 20, 2025 · PreprintNeuroscience

Remote Cortical Network for Frontal Cognitive Symptoms Derived from Tau Accumulation in Progressive Supranuclear Palsy

Yuki Hori, Hironobu Endo, Kenji Tagai, Yuko Kataoka, Ryoji Goto, Shin Kurose, Yuki Momota, Naomi Kokubo, Chie Seki, Sho Moriguchi, Hitoshi Shimada, Hitoshi Shinotoh, Takahiko Tokuda, Keisuke Takahata, Takafumi Minamimoto, , Toshiyuki Hirabayashi

This study identifies a cortical network linked to frontal cognitive symptoms in PSP through remote effects of tau deposits, independent of atrophy.

bioRxiv · Feb 5, 2025 · PreprintNeuroscience

Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases

Hironobu Endo, Maiko Ono, Yuhei Takado, Kiwamu Matsuoka, Manami Takahashi, Kenji Tagai, Yuko Kataoka, Kosei Hirata, Keisuke Takahata, Chie Seki, Naomi Kokubo, Masayuki Fujinaga, Wakana Mori, Yuji Nagai, Koki Mimura, , Makoto Higuchi

This study develops a PET ligand to visualize α-synuclein pathologies in Parkinson's and DLB patients, showing increased signals in affected brain regions.

Neuron · Jun 5, 2024Peer-reviewedNeuroscience