Ming‐Rong Zhang

This paper introduces NARCH, a chemogenetic method to reversibly inhibit endogenous receptors in specific cell types in vivo, demonstrating its use in studying mGlu1 signaling in Purkinje cells.

This study investigates how dopamine affects brain metastate dynamics using a combination of PET, fMRI, and hidden Markov modeling, finding that dopamine shifts the balance between internally oriented and sensorimotor-perceptual brain states.

This study longitudinally assesses DREADD expression and efficacy in macaque monkeys using PET imaging and functional studies, showing peak expression at 60 days and sustained effects for two years.

This study develops a PET ligand to visualize α-synuclein pathologies in Parkinson's and DLB patients, showing increased signals in affected brain regions.

The paper validates and optimizes the PSAM/PSEM chemogenetic system in nonhuman primates using multimodal imaging techniques to determine optimal agonist, dose, and timing for neuronal manipulation.

The paper develops a PET probe to visualize intracellular pH gradients in the brain by monitoring monoacylglycerol lipase activity under varying pH conditions.

This study shows that 5-HT1A and 5-HT1B receptor blockade separately affects motivation by altering sensitivity to cost and reward in monkeys.

The paper identifies a whole-brain neural network predicting superiority illusion and striatal dopamine levels using resting-state fMRI data.

The paper investigates the relationship between behavioral inhibition system scores and 5-HT2A receptor availability in the anterior cingulate cortex, identifying a functional connectivity network involving the left middle frontal gyrus.

This paper develops and evaluates [11C]26, a PET probe for imaging PDE7 in the brain, showing promising in vitro performance and moderate specific binding in nonhuman primates.

This paper develops [11C]MTP38 as a PET ligand for PDE7 and demonstrates its preclinical success in imaging PDE7 in the brain.

This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

This paper develops a PET-based method using ecDHFR and TMP analogs to image neuronal networks in mammalian brains, enabling visualization of neuronal activity and protein dynamics.