Chie Seki

This study investigates how dopamine affects brain metastate dynamics using a combination of PET, fMRI, and hidden Markov modeling, finding that dopamine shifts the balance between internally oriented and sensorimotor-perceptual brain states.

This study identifies a cortical network linked to frontal cognitive symptoms in PSP through remote effects of tau deposits, independent of atrophy.

This study develops a PET ligand to visualize α-synuclein pathologies in Parkinson's and DLB patients, showing increased signals in affected brain regions.

The paper investigates the relationship between behavioral inhibition system scores and 5-HT2A receptor availability in the anterior cingulate cortex, identifying a functional connectivity network involving the left middle frontal gyrus.

This paper develops [11C]MTP38 as a PET ligand for PDE7 and demonstrates its preclinical success in imaging PDE7 in the brain.

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

This paper develops a PET-based method using ecDHFR and TMP analogs to image neuronal networks in mammalian brains, enabling visualization of neuronal activity and protein dynamics.