Tetsuya Suhara

This study investigates how dopamine affects brain metastate dynamics using a combination of PET, fMRI, and hidden Markov modeling, finding that dopamine shifts the balance between internally oriented and sensorimotor-perceptual brain states.

This study develops a PET ligand to visualize α-synuclein pathologies in Parkinson's and DLB patients, showing increased signals in affected brain regions.

This study shows that 5-HT1A and 5-HT1B receptor blockade separately affects motivation by altering sensitivity to cost and reward in monkeys.

This study disrupts the connection between the orbitofrontal cortex and rostromedial caudate nucleus in macaques using chemogenetics, showing it impairs reward-based motivational control of goal-directed actions.

The paper identifies a whole-brain neural network predicting superiority illusion and striatal dopamine levels using resting-state fMRI data.

This study identifies resting-state brain connectivity patterns that predict individual aptitude in fMRI-neurofeedback training, independent of targeted brain regions.

The paper examines how resting-state functional connectivity relates to individual differences in positive memory recollection, identifying a frontotemporal network associated with positive memory performance.

This study uses DREADD technology in common marmosets to show that chemogenetic activation of nigrostriatal dopamine neurons induces contralateral rotation behavior.

The paper shows that neurons in the primate caudate head encode temporally discounted value for delayed rewards, essential for motivation.

The paper investigates the relationship between behavioral inhibition system scores and 5-HT2A receptor availability in the anterior cingulate cortex, identifying a functional connectivity network involving the left middle frontal gyrus.

This study investigates how D1-like and D2-like dopamine receptors influence cost/benefit evaluation and motivation in monkeys using pharmacological manipulation and PET imaging.

This study uses chemogenetic methods to selectively silence prefronto-subcortical pathways in monkeys, revealing distinct roles in working memory and decision-making.

This study tracks tau fibrillogenesis and microglial phagocytosis of neurons in a living tauopathy model, showing that microglia engulf tangle-bearing neurons and that TSPO ligands can reduce this process.

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

This paper develops a PET-based method using ecDHFR and TMP analogs to image neuronal networks in mammalian brains, enabling visualization of neuronal activity and protein dynamics.

This study investigates how the ventral pallidum and rostromedial caudate encode reward size and satiation level in macaques performing a lever-release task, showing VP has stronger coding and more severe inactivation effects on goal-directed behavior.