Yuki Hori

Longitudinal assessment of DREADD expression and efficacy in the monkey brain

This study longitudinally assesses DREADD expression and efficacy in macaque monkeys using PET imaging and functional studies, showing peak expression at 60 days and sustained effects for two years.

Modular dynamics of conscious and unconscious states in marmoset cortex

This study examines how isoflurane affects functional brain networks in marmosets, finding reduced network dynamics and increased similarity to anatomical structure under anaesthesia.

Establishment of a second-generation transgenic marmoset model of polyglutamine disease recapitulating neurological symptoms and pathology

This paper describes a second-generation transgenic marmoset model of SCA3 that replicates motor impairments and neuropathology, offering a platform for studying disease mechanisms and therapies.

Remote Cortical Network for Frontal Cognitive Symptoms Derived from Tau Accumulation in Progressive Supranuclear Palsy

This study identifies a cortical network linked to frontal cognitive symptoms in PSP through remote effects of tau deposits, independent of atrophy.

Distinct roles of monkey OFC-subcortical pathways in adaptive behavior

This study identifies distinct OFC-subcortical pathways in macaques that support experience-based and inference-based value updating during adaptive decision-making.

Multimodal imaging for validation and optimization of ion channel-based chemogenetics in nonhuman primates

The paper validates and optimizes the PSAM/PSEM chemogenetic system in nonhuman primates using multimodal imaging techniques to determine optimal agonist, dose, and timing for neuronal manipulation.

Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys

This study shows that 5-HT1A and 5-HT1B receptor blockade separately affects motivation by altering sensitivity to cost and reward in monkeys.

Chemogenetic disconnection between the orbitofrontal cortex and the rostromedial caudate nucleus disrupts motivational control of goal-directed action

This study disrupts the connection between the orbitofrontal cortex and rostromedial caudate nucleus in macaques using chemogenetics, showing it impairs reward-based motivational control of goal-directed actions.

Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain

This paper develops a non-invasive multi-modal neuroimaging pipeline for precise brain targeting in marmosets, revealing significant intersubject variability and creating new population-based templates.

Simultaneous functional MRI of socially interacting marmosets

This paper introduces a method to simultaneously measure whole-brain activation in two socially interacting marmoset monkeys using functional MRI and finds neuronal synchrony in brain regions involved in social processing.

Functional organization of frontoparietal cortex in the marmoset investigated with awake resting-state fMRI

This study investigates the functional organization of frontoparietal networks in marmosets using resting-state fMRI, finding patterns similar to macaques.

Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas

This study uses movie-driven fMRI to identify whole-brain functional correspondences between marmosets and humans, finding conserved higher-order visual areas but species-specific responses to animal faces.

Whole brain mapping of somatosensory responses in awake marmosets investigated with ultra-high field fMRI

This paper maps somatosensory responses in awake marmosets using fMRI, finding body representations in cortical and subcortical regions similar to Old World primates and humans.

Cortico-subcortical functional connectivity profiles of resting-state networks in marmosets and humans

This study compares cortico-subcortical functional connectivity in marmosets and humans using resting-state fMRI, finding both similarities and species-specific differences in network patterns.

Visual looming and receding networks in awake marmosets investigated with fMRI

The paper uses fMRI in awake marmosets to identify brain networks activated by looming and receding visual stimuli, finding distinct patterns associated with looming that may support protective behaviors.

Towards HCP-Style Macaque Connectomes: 24-Channel 3T Multi-Array Coil, MRI Sequences and Preprocessing

The paper develops a 24-channel MRI coil and adapts HCP protocols for macaques, enabling high-quality in vivo imaging and preprocessing comparable to human studies.