Identification of translation events that drive nonsense-mediated mRNA decay reveals functional roles for noncoding RNAs
David J. Young, Yuejun Wang, Nicholas R. Guydosh
bioRxiv · Aug 15, 2025 · PreprintMolecular Biology
Author
David J. Young
National Institutes of HealthORCID 0000-0002-0885-8568Unclaimed ORCID profile · follow to get notified of new preprints
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2020-2025 · peak 1/yrCo-Author Collaboration Network
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In vivo tracking of ex vivo generated 89Zr-oxine labeled plasma cells by PET in a non-human primate model
David J. Young, Abigail J Edwards, Kevin G Quiroz Caceda, Ella Liberzon, Johana Barrientos, So Gun Hong, Jacob Turner, Peter L. Choyke, Sean P. Arlauckas, Adam S. Lazorchak, Richard A. Morgan, Noriko Sato, Cynthia E. Dunbar
The paper demonstrates a method to track ex vivo generated B cells in non-human primates using PET imaging, showing stable distribution and feasibility of repeated infusions.
Molecular Therapy · Dec 30, 2024Peer-reviewedBioengineering
Validation and Long-Term Follow Up of CD33 Off-Targets Predicted In Vitro and In Silico Using Error-Corrected Sequencing in Rhesus Macaques
Aisha A. Aljanahi, Cícera Regina Lazzarotto, Shirley Chen, Tae–Hoon Shin, Stefan Cordes, Isabel Jabara, Yifan Zhou, David J. Young, Byung‐Chul Lee, Kyung–Rok Yu, Yuesheng Li, Bradley S. Toms, Ilker Tunc, So Gun Hong, Lauren L. Truitt, , Cynthia E. Dunbar
The paper validates off-target effects of CRISPR/Cas9 in rhesus macaques using error-corrected sequencing, showing that in vitro and in silico methods have limited predictive accuracy.
bioRxiv · Jul 5, 2020 · PreprintMolecular Biology