Manimozhiyan Arumugam

FastaLake selects compact metaproteomic databases from large sequence reservoirs by de novo peptide lookup

FastaLake constructs compact metaproteomic databases from sequence resources to improve peptide identification without requiring matched metagenomic sequencing.

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

This study shows that fecal microbial load, not disease, is the main driver of gut microbiome changes and identifies it as a major confounder in microbiome studies.

Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study.

The paper identifies shared genetic regulation across mRNA, proteins, and metabolites in blood, revealing networks and mediators of GWAS variants.

Pharmacogenomics of GLP-1 Receptor Agonists: A genome-wide analysis of observational data and large randomized controlled trials

This study identifies genetic variants associated with glycaemic response to GLP-1 receptor agonists using observational and trial data, finding variants in GLP-1R and ARRB1 linked to HbA1c reduction.

Metagenomic evidence for co-occurrence of antibiotic, biocide and metal resistance genes in pigs

The paper analyzes gut metagenomes from pigs to investigate co-occurrence patterns of antibiotic resistance genes (ARGs) with metal and biocide resistance genes, finding non-random phylogenetic associations.

Implementations of the chemical structural and compositional similarity metric in R and Python

The paper provides efficient implementations of the Chemical Structural and Compositional Similarity metric in R and Python, significantly improving speed and usability for metabolomics analysis.