Author

Nicholas Thom

Broad InstituteORCID 0000-0002-0959-7590Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Nicholas Thom1 paper · University of Chicago

Biology Disciplines

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Neuroscience· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Jimena AnderseniD· 2 shared Se‐Jin YooniD· 2 shared Sergiu P. PașcaiD· 2 shared Xiaoyu CheniD· 2 shared Anca M. PașcaiD· 1 shared Christine E. PetersiD· 1 shared Evan Z. MacoskoiD· 1 shared Fabian MülleriD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Jimena AndersenORCID

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3 papers

Recent·Most cited

Human assembloid model of emergent neurotropic enteroviruses

Christine E. Peters, Jimena Andersen, Min-Yin Li, Lauren Varanese, Mayuri Vijay Thete, Se‐Jin Yoon, Taylor Pio, Nicholas Thom, Xiaoyu Chen, Wenjie Qiao, Jan E. Carette, Sergiu P. Pașca

The paper describes a human assembloid model to study enterovirus pathogenesis, showing that different EVs cause muscle contraction loss through distinct cellular mechanisms.

bioRxiv · Nov 18, 2025 · PreprintNeuroscience

Cassini: Streamlined and Scalable Method for in situ profiling of RNA and Protein

Nicolas Lapique, Michael Tae-jong Kim, Nicholas Thom, Naeem M. Nadaf, Juan Pineda, Evan Z. Macosko

Cassini enables cost-effective, multiplexed profiling of mRNA and protein in tissue samples with high sensitivity and speed.

Nature Communications · Oct 1, 2025Peer-reviewedBioengineering

Landscape of human spinal cord cell type diversity at midgestation

Jimena Andersen, Nicholas Thom, Jennifer L. Shadrach, Xiaoyu Chen, Neal D. Amin, Se‐Jin Yoon, William James Greenleaf, Fabian Müller, Anca M. Pașca, Julia A. Kaltschmidt, Sergiu P. Pașca

The paper profiles midgestation human spinal cord cells at single-cell resolution, revealing early diversification of motor neurons and glial cell types.

bioRxiv · Dec 29, 2021 · PreprintNeuroscience