Matthew Pan

This study shows that chlamydial histones HctA and HctB are essential for transgenerational developmental fitness, as their deficiency during EB maturation impairs subsequent infection cycles.

The paper identifies a heat-induced negative feedback loop in Chlamydia involving HagF and HrcA that modulates chaperone gene expression and promotes infectious elementary body formation under stress.

This study identifies Pgp2 as a plasmid replication initiator in Chlamydia, showing its beta-hairpin motif is essential for iteron-binding and plasmid replication.