Danny Wan

This study identifies four coordinated transcriptional programs in Chlamydia trachomatis during its developmental cycle using time-course RNA sequencing.

This study compares transcriptomic responses of Chlamydia trachomatis to different stressors, revealing distinct reprogramming and shared features across conditions.

The paper identifies a heat-induced negative feedback loop in Chlamydia involving HagF and HrcA that modulates chaperone gene expression and promotes infectious elementary body formation under stress.

This study identifies Pgp2 as a plasmid replication initiator in Chlamydia, showing its beta-hairpin motif is essential for iteron-binding and plasmid replication.

The paper addresses challenges in differential expression analysis of Chlamydia RNA-Seq data by proposing normalization methods that better capture transcriptomic activation, validated through qRT-PCR.

The paper identifies CTL0286 as the chlamydial RNA polymerase omega subunit and shows it is conserved across obligate intracellular bacteria.