Huizhou Fan

This study identifies four coordinated transcriptional programs in Chlamydia trachomatis during its developmental cycle using time-course RNA sequencing.

This study shows type I and II interferons have distinct and overlapping roles in controlling Chlamydia trachomatis infection in the female genital tract, with type I acting earlier and type II later, and both critical for suppression at different stages and locations.

This study compares transcriptomic responses of Chlamydia trachomatis to different stressors, revealing distinct reprogramming and shared features across conditions.

This study identifies Collaborative Cross mouse strains susceptible to chlamydial induction of hydrosalpinx, revealing strain-specific differences in infection and pathology outcomes.

This study shows that chlamydial histones HctA and HctB are essential for transgenerational developmental fitness, as their deficiency during EB maturation impairs subsequent infection cycles.

This study identifies a dendritic cell-intrinsic TLR/MyD88/IL-23 pathway that promotes clearance of a live-attenuated oral vaccine in the large intestine.

The paper identifies a heat-induced negative feedback loop in Chlamydia involving HagF and HrcA that modulates chaperone gene expression and promotes infectious elementary body formation under stress.

This study identifies Pgp2 as a plasmid replication initiator in Chlamydia, showing its beta-hairpin motif is essential for iteron-binding and plasmid replication.

The paper addresses challenges in differential expression analysis of Chlamydia RNA-Seq data by proposing normalization methods that better capture transcriptomic activation, validated through qRT-PCR.

The paper identifies CTL0286 as the chlamydial RNA polymerase omega subunit and shows it is conserved across obligate intracellular bacteria.

This paper shows that GrgA regulates Chlamydia trachomatis growth and development by controlling transcription factors Euo and HrcA, and a virulence factor PmpI.