Author

John A. Cobb

University of CalgaryORCID 0000-0002-1053-2604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Aditya SaxenaiD· 1 shared Amanda BirminghamiD· 1 shared Anja LjubojeviciD· 1 shared Axel ViseliD· 1 shared Bénédicte MascreziD· 1 shared Brandon J. MannioniD· 1 shared Cailyn H. SpurrelliD· 1 shared Carly S. SullivaniD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperDevelopmental Biology

Aditya SaxenaORCID

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3 papers

Recent·Most cited

A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival

Samuel Abassah‐Oppong, Brandon J. Mannion, Matteo Zoia, Raquel Rouco, Virginie Tissières, Cailyn H. Spurrell, Virginia Roland, Fabrice Darbellay, Anja Ljubojevic, Julie Gamart, Tabitha A. Festa-Daroux, Carly S. Sullivan, Eddie Rodríguez-Carballo, Y. Fukuda, Riana D. Hunter, , Marco Osterwalder

This study identifies a gene desert critical for Shox2 regulation and embryonic survival through enhancer networks in mouse development.

bioRxiv · Nov 22, 2020 · PreprintDevelopmental Biology

Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion

Aditya Saxena, Virag Sharma, Stanley J. Neufeld, Mai P. Tran, Haydee L. Gutierrez, Joel M. Erberich, Amanda Birmingham, John A. Cobb, Michael Hiller, Kimberly L. Cooper

The paper identifies genes controlling limb skeletal proportion differences between mouse and jerboa by comparing transcriptomes of growth cartilages and finding species-specific expression patterns.

bioRxiv · Sep 26, 2019 · PreprintDevelopmental Biology

Single-cell mRNA profiling reveals heterogeneous combinatorial expression of Hoxd genes during limb development

Pierre J. Fabre, Marion Leleu, Bénédicte Mascrez, Quentin Lo Giudice, John A. Cobb, Denis Duboule

The paper analyzes single-cell transcriptomes of developing mammalian limb buds to show that Hoxd genes are expressed in specific combinations linked to cell types and follow a pseudotime trajectory during digit development.

BMC Biology · Sep 14, 2018Peer-reviewedDevelopmental Biology