Pierre J. Fabre

The paper shows that FGF and Wnt signaling gradients determine phase transitions in vertebrate eye cup development, specifying cell fates through their combinatorial code.

This study uses single-cell mRNA profiling to reveal the transcriptional logic of cell fate specification and axon guidance in early retinal neurons, identifying new molecular markers and regulatory sequences.

The paper analyzes single-cell transcriptomes of developing mammalian limb buds to show that Hoxd genes are expressed in specific combinations linked to cell types and follow a pseudotime trajectory during digit development.

The paper investigates the HoxD cluster's role as a dynamic TAD boundary in limb development, showing its resilience and ability to maintain regulatory segregation.

The paper investigates how genomic rearrangements affect TAD structures at the HoxD locus by analyzing long-range chromatin interactions and boundary selection mechanisms.