The paper identifies a high-affinity master docking motif on CENP-U that interacts extensively with PLK1's Polo-box domain, suggesting common features among master PLK1 docking motifs.

Nature Communications · May 11, 2026Peer-reviewedBiochemistry

Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3

Elisabeth Hennes, Belén Lucas, Natalie S. Scholes, Xiu‐Fen Cheng, Daniel C. Scott, Matthias Bischoff, Katharina Reich, Raphael Gasper, María Lucas, Teng Teng Xu, Sofia Rossini, Lisa‐Marie Pulvermacher, Lara Dötsch, Hana Imrichová, Alexandra Brause, , Herbert Waldmann

The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.

Nature Chemistry · Jan 7, 2026Peer-reviewedCell Biology

Structural insights into late-stage photosystem II assembly by Psb32

Stefan Bohn, Yat Kei Lo, Jan Lambertz, Jakob Meier-Credo, Torben Fürtges, Pasqual Liauw, Raphael Gasper-Schönenbrücher, Dennis Wiens, Julian D. Langer, Georg Hochberg, Eckhard Hofmann, Till Rudack, Marc M. Nowaczyk, Jan M. Schuller

This study determines the structure of two late-stage PSII assembly intermediates, revealing how Psb32 and Psb27 regulate OEC maturation and Mn4O5Ca cluster preparation.

bioRxiv · May 8, 2025 · PreprintPlant Biology