Cell BiologyNature ChemistryPeer-reviewed
Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3
Elisabeth Hennes, Belén Lucas, Natalie S. Scholes…·Herbert Waldmann
The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.
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