Author

Sara Svensson Akusjärvi

Karolinska InstitutetORCID 0000-0002-1086-5409Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Anoop T. AmbikaniD· 2 shared Flora MikaeloffiD· 2 shared Ronaldo Lira‐JunioriD· 2 shared Soham GuptaiD· 2 shared Ujjwal NeogiiD· 2 shared Ahmet Sadık YalçınkayaiD· 1 shared Ákos VégváriiD· 1 shared Alejandra EscósiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Anoop T. AmbikanORCID

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2 papers

Recent·Most cited

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19

Ronaldo Lira‐Junior, Anoop T. Ambikan, Axel Cederholm, Sefanit Rezene, Flora Mikaeloff, Sara Svensson Akusjärvi, Ahmet Sadık Yalçınkaya, Xi Chen, Maike Sperk, Maribel Aranda Guillen, Hampus Nordqvist, Carl Johan Treutiger, Nils Landegren, Ujjwal Neogi, Soham Gupta

This study identifies ISG expression endotypes in COVID-19 patients and links lipid metabolism to immune dysfunction in severe disease.

Genome Medicine · May 29, 2026Peer-reviewedImmunology

Altered Glycolysis TCA Anaplerosis Axis Impairs Monocyte Migration and Trains Macrophage Polarization in Long-term Treated HIV Infection

Alejandra Escós, Anoop T. Ambikan, Sabrina Schulster, Sara Svensson Akusjärvi, Marco Gelpi, Siavash Mansouri, Prajakta Naval, Ronaldo Lira‐Junior, Vikas Sood, Andreas Dehlbæk Knudsen, Pratik P Pathade, Flora Mikaeloff, Julie Høgh, Magda Lourda, Jan Vesterbacka, , Ujjwal Neogi

The paper identifies metabolic reprogramming in HIV-treated individuals that impairs monocyte migration and promotes M2-like macrophage polarization, enhancing HIV susceptibility.

bioRxiv · Jan 15, 2025 · PreprintSystems Biology