Author

Xi Chen

Karolinska InstitutetORCID 0000-0002-5166-0872Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Xi Chen11 papers · AstraZeneca (United States)

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Ahmet Sadık YalçınkayaiD· 1 shared Akihiro C. E. ShibataiD· 1 shared Aliza B. Rubenstein· 1 shared Anoop T. AmbikaniD· 1 shared Antonio CappuccioiD· 1 shared Ardalan HendiiD· 1 shared Axel CederholmiD· 1 shared Bei WeiiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperImmunology

Ahmet Sadık YalçınkayaORCID

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4 papers

Recent·Most cited

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19

Ronaldo Lira‐Junior, Anoop T. Ambikan, Axel Cederholm, Sefanit Rezene, Flora Mikaeloff, Sara Svensson Akusjärvi, Ahmet Sadık Yalçınkaya, Xi Chen, Maike Sperk, Maribel Aranda Guillen, Hampus Nordqvist, Carl Johan Treutiger, Nils Landegren, Ujjwal Neogi, Soham Gupta

This study identifies ISG expression endotypes in COVID-19 patients and links lipid metabolism to immune dysfunction in severe disease.

Genome Medicine · May 29, 2026Peer-reviewedImmunology

Innate immune epigenomic landscape following controlled human influenza virus infection

William Thistlethwaite, Sindhu Vangeti, Wan-Sze Cheng, Pankaj Agarwal, Antonio Cappuccio, Wenliang Wang, Bei Wei, Rachel A. Myers, Aliza B. Rubenstein, Daniel G. Chawla, Manoj Hariharan, Micah T. McClain, Thomas W. Burke, Steven H. Kleinstein, Joseph R. Ecker, , Stuart C. Sealfon

The paper analyzes the epigenomic changes in innate immune cells after influenza virus infection and finds coordinated rewiring of the epigenetic landscape.

Cell Reports · Sep 17, 2025Peer-reviewedImmunology

Engineered mitochondrial A-to-G editors with enhanced efficiency and targeting scope

Liang Chen, Mengjia Hong, Changming Luan, Meng Yuan, Yiming Wang, Xinyuan Guo, Yue Fang, Hao Huang, Xiaohua Dong, Hongyi Gao, Dan Zhang, Xi Chen, Dong Meng, Molin Huang, Zongyi Yi, , Dali Li

This paper develops eTd-mtABEs, engineered mitochondrial A-to-G base editors with enhanced efficiency and targeting scope, enabling efficient generation of mtDNA disease models in rat embryos.

Nature Biotechnology · Jun 3, 2025Peer-reviewedBioengineering

Rap2 and TNIK control Plexin-dependent synaptic tiling in C. elegans

Xi Chen, Akihiro C. E. Shibata, Ardalan Hendi, Mizuki Kurashina, Ethan Fortes, Nicholas L. Weilinger, Brian A. MacVicar, Hideji Murakoshi, Kota Mizumoto

This study identifies Rap2 and TNIK as regulators of Plexin-dependent synaptic tiling in C. elegans, showing their role in restricting presynaptic assembly and forming tiled innervation.

eLife · Jul 31, 2018Peer-reviewedNeuroscience