Jordan S. Kesner

This study identifies ADAMTS7's role in promoting atherosclerosis by enhancing smooth muscle cell foam cell formation via an AP-1/PU.1/CD36 pathway.

The paper identifies a fail-safe mechanism for surveilling translation in noncoding regions, showing that hydrophobic C-terminal tails of noncoding-derived polypeptides are targeted by the BAG6 complex for degradation or membrane localization.

This paper demonstrates that targeting a single marker RNA with CRISPR/RfxCas13d causes collateral transcriptome destruction, enabling inhibition of cell proliferation or suppression of cell state transition in human cells.