Author

Michelle R. King

Babraham InstituteORCID 0000-0002-1124-9317Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Organism:yeast· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jonathan M. HouseleyiD· 3 shared Felix KruegeriD· 2 shared Ryan M. HulliD· 2 shared Alex J. WhaleiD· 1 shared Christel KruegeriD· 1 shared Cristina CruziD· 1 shared Dorottya HorkaiiD· 1 shared Grazia Pizza· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMolecular Biology

Jonathan M. HouseleyORCID

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3 papers

Recent·Most cited

Stimulation of adaptive gene amplification by origin firing under replication fork constraint

Alex J. Whale, Michelle R. King, Ryan M. Hull, Felix Krueger, Jonathan M. Houseley

The paper investigates how transcriptional activation of the CUP1 gene in budding yeast leads to copy number variation through replication stress and homologous recombination.

Nucleic Acids Research · Dec 6, 2021Peer-reviewedMolecular Biology

Transcription-induced formation of extrachromosomal DNA during yeast ageing

Ryan M. Hull, Michelle R. King, Grazia Pizza, Felix Krueger, Xabier Vergara, Jonathan M. Houseley

This study shows that transcription of the CUP1 gene in aged yeast leads to the formation of extrachromosomal DNA, which accumulates without phenotypic selection and is site-specific.

PLoS Biology · Dec 3, 2019Peer-reviewedMolecular Biology

Tri-methylation of Histone H3 Lysine 4 Facilitates Gene Expression in Ageing Cells

Cristina Cruz, Monica Della Rosa, Christel Krueger, Qian Gao, Dorottya Horkai, Michelle R. King, Lucy Field, Jonathan M. Houseley

This study shows that H3K4me3 is essential for maintaining normal gene expression levels across yeast lifespan, with COMPASS mutations reducing lifespan and causing gene expression defects.

eLife · Oct 1, 2018Peer-reviewedGenetics