Ryan M. Hull

This paper introduces s5PSeq, a streamlined protocol for rapid antimicrobial sensitivity testing using 5P mRNA degradation intermediates, demonstrating its clinical utility in identifying resistant Clostridioides difficile isolates.

The paper shows that XRN1-mediated RNA decay provides nucleotides for alphavirus replication by recycling monophosphate nucleotides through the salvage pathway.

The paper investigates how transcriptional activation of the CUP1 gene in budding yeast leads to copy number variation through replication stress and homologous recombination.

This study shows that transcription of the CUP1 gene in aged yeast leads to the formation of extrachromosomal DNA, which accumulates without phenotypic selection and is site-specific.