Alessandro De Simone

A moving front of osteoblast maturation scales regenerating zebrafish bone

The paper identifies a moving front of osteoblast maturation that controls proliferation during zebrafish scale regeneration, explaining size scaling through regulated cell dynamics.

Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration

The paper quantifies Erk signaling gradients in zebrafish fin regeneration and shows they scale with tissue amputation size to control skeletal regeneration.

Transcriptional feedback of Erk signaling waves in zebrafish scale regeneration

The paper shows Erk signaling waves in zebrafish scale regeneration induce inhibitor transcript waves and modulate osterix transcription, linking wave dynamics to tissue growth and maturation.

Reconstruction and deconstruction of human somitogenesis in vitro

This study introduces 3D culture systems to model human somitogenesis, revealing the role of the segmentation clock in establishing somite compartments.

Mathematical modeling of Erk activity waves in regenerating zebrafish scales

The paper develops a reaction-diffusion model to explain Erk activity waves in zebrafish scale regeneration, showing how feedback loops control wave properties and propagation.

PI(4,5)P2 forms dynamic cortical structures and directs actin distribution and cell polarity in C. elegans embryos

The paper shows that PIP2 forms dynamic cortical structures in C. elegans embryos, regulating actin organization and cell polarity during asymmetric division.