Pierre Gönczy

The paper reconstitutes synthetic centrioles using an engineered platform and shows that procentriole number scales with platform surface area, revealing a mechanism for organelle number homeostasis.

The paper develops a 3D mechanical model of C. elegans zygote polarization, showing how nematic cortical structures ensure robust axis alignment during polarization.

This study shows SAS-1 is essential for centriole integrity and ciliary function in C. elegans and interacts with SSNA-1 to maintain these structures.

This study identifies mechanisms by which Naegleria gruberi eliminates axonemes and centrioles during life cycle reversion, revealing lysosomal and proteasome-dependent pathways and extracellular shedding.

Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.

The paper maps centriolar and PCM core protein localization in C. elegans post-embryonic lineage, showing cell fate determines centriole retention.

The paper shows that sperm-contributed centrioles are distributed stochastically in C. elegans 4-cell stage embryos, contrasting with some asymmetric divisions.

The paper quantifies sex-specific small RNAomes in C. elegans and identifies sex- and tissue-specific differences in RNAi resistance.

The paper shows that PIP2 forms dynamic cortical structures in C. elegans embryos, regulating actin organization and cell polarity during asymmetric division.