Margarete Díaz-Cuadros

This paper identifies a genetic bottleneck in the G3P shuttle that limits human developmental rate by constraining metabolic flux and the segmentation clock.

The paper shows that metabolic rates influence developmental speed in mouse and human embryos, with mouse cells having higher metabolic rates and faster segmentation clock periods.

This study introduces 3D culture systems to model human somitogenesis, revealing the role of the segmentation clock in establishing somite compartments.

This study shows that mechanical tension drives multi-scale self-organisation in human iPSC-derived muscle fibers by coordinating sarcomere assembly and myofiber bundling.

The paper identifies a human segmentation clock by showing human PSM cells exhibit Notch and YAP-dependent oscillations of HES7 with a 5-hour period.