Hauke S. Hillen

Structure of the human mitochondrial RNA degradosomereveals a distinct mode of helicase-nuclease coupling

The paper determines the cryo-EM structure of the human mitochondrial RNA degradosome, revealing a unique helicase-nuclease coupling mechanism.

Mechanism of human tRNA 3'CCA maturation

This study elucidates the mechanism of human tRNA 3'CCA maturation by determining TRNT1 structures and showing a continuous polymerization and translocation mechanism.

FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites

This study identifies FASTKD5 as essential for processing non-canonical mitochondrial mRNAs and reveals its substrate-specific cleavage mechanism.

Structural basis of Nipah virus replication

This study presents cryo-EM structures of Nipah virus RdRp in apo and early elongation states, revealing its architecture and RNA interaction mechanisms.

Molecular basis of human nuclear and mitochondrial tRNA 3'-processing

The paper identifies the molecular mechanisms by which ELAC2 processes nuclear and mitochondrial tRNAs, revealing distinct roles for TRMT10C and SDR5C1 in mitochondrial tRNA maturation.

Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling

This study defines the molecular mechanism of GTPase-mediated mitochondrial ribosome biogenesis and recycling using cryo-EM and biochemical approaches.

Dimeric form of SARS-CoV-2 polymerase

The paper reports a dimeric structure of SARS-CoV-2 RdRp and suggests it may facilitate template switching during transcription.