Frank S. Vago

Identifying differential effects from eleven mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance

The paper compares the effects of eleven mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance, finding significant differences in particle properties and performance across methods.

Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia

The paper determines that tau and TMEM106B filaments from gray and white matter in MSTD have identical folds.

Cryo-EM structure of Escherichia coli σ70 RNAP and promoter DNA complex revealed a role of σ nonconserved region during the open complex formation

The paper determines the cryo-EM structure of E. coli σ70 RNAP and promoter DNA complex, revealing a role of σNCR in open complex formation.