Sergei R. Doulatov

The paper identifies multi-hit STAG2 mutations in MDS patients, showing they are associated with worse outcomes and suggest convergent evolutionary targeting of the cohesin gene.

HiCFoundation is a Hi-C-based model that integrates chromatin structure with epigenomic regulation across species, improving analysis of 3D genome architecture and single-cell data.

The paper maps single-cell dynamics of endothelial-to-hematopoietic transition from iPSCs and identifies FGF signaling modulation to improve hematopoietic output.

This study identifies CDK8 mis-splicing as a driver of altered progenitor fate in SF3B1-mutant MDS, linking splicing defects to transcriptional dysregulation and lineage commitment.