Author

Vella Nikolova

Universitätsmedizin GöttingenORCID 0000-0002-1334-3008Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Matthias DobbelsteiniD· 3 shared Karen Linnemannstöns· 2 shared Markus GanteriD· 2 shared Anastasiia Zahoruiko· 1 shared Antje DickmannsiD· 1 shared Benedikt GanteriD· 1 shared Bernd WollnikiD· 1 shared Carsten G. K. LüderiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

Matthias DobbelsteinORCID

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3 papers

Recent·Most cited

MicrobiologyACS Infectious DiseasesPeer-reviewedOct 3, 2025

Membrane-permeable 5-fluorodeoxyuridine triphosphate derivatives inhibit the proliferation of Plasmodium falciparum

Vella Nikolova, Karen Linnemannstöns, Marie-Elise Bendel…·Matthias Dobbelstein

The paper tests cell-permeable 5-fluorodeoxyuridine triphosphate derivatives against Plasmodium falciparum and finds they inhibit parasite proliferation while being selectively rescued by thymidine in human cells.

1 citation

plant (other)experimental assay

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MicrobiologybioRxivPreprintMar 14, 2025

Synergistic activity of the ferroptosis inducer RSL3 and Pyrimethamine to inhibit the proliferation of Plasmodium falciparum

Vella Nikolova, Karen Linnemannstöns, Anastasiia Zahoruiko…·Matthias Dobbelstein

This study shows that RSL3 and Pyrimethamine synergistically inhibit Plasmodium falciparum growth, with a mechanism distinct from canonical ferroptosis.

DOI 10.1101/2025.03.14.643256

plant (other)experimental assay

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Molecular BiologyVirus ResearchPeer-reviewedJun 6, 2021

The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models

Kim M. Stegmann, Antje Dickmanns, Sabrina Gerber…·Matthias Dobbelstein

This paper shows that methotrexate inhibits SARS-CoV-2 replication in cell cultures and synergizes with remdesivir, suggesting potential for repurposing MTX in treating COVID-19.

50 citations

humanbulk RNA-seq

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