Molecular BiologybioRxivPreprint
Recognition of HIV-1 capsid licenses innate immune response to viral infection
Sunnie M. Yoh, João I. Mamede, Derrick Lau…·Sumit K. Chanda
The paper identifies a two-factor authentication mechanism used by the innate immune system to detect low-abundance HIV-1 DNA through PQBP1-mediated capsid recognition and cGAS recruitment.
DOI 10.1101/2022.01.10.472699