Recognition of HIV-1 capsid licenses innate immune response to viral infection
Sunnie M. Yoh, João I. Mamede, Derrick Lau, Narae Ahn, María Teresa Sánchez-Aparicio, Joshua E. Temple, Andrew Tuckwell, Nina V. Fuchs, Gianguido C. Cianci, Laura Riva, Heather M. Curry, Xin Yin, Stéphanie Gambut, Lacy M. Simons, Judd F. Hultquist, , Sumit K. Chanda
The paper identifies a two-factor authentication mechanism used by the innate immune system to detect low-abundance HIV-1 DNA through PQBP1-mediated capsid recognition and cGAS recruitment.
bioRxiv · Jan 10, 2022 · PreprintMolecular Biology