An IL-12 mRNA-LNP adjuvant enhances mRNA vaccine induced CD8+ T cell responses
Emily A. Aunins, Anthony T. Phan, Mohamad‐Gabriel Alameh, Garima Dwivedi, Elisa Cruz-Morales, David A. Christian, Ying K. Tam, Molly E. Bunkofske, Anabel Zabala-Peñafiel, Keenan M. O’Dea, Maria I. Merolle, Colleen Furey, Phillip Scott, Robert H. Vonderheide, Scott E. Hensley, , Christopher A. Hunter
This study shows that adding IL-12 mRNA-LNPs to an mRNA vaccine enhances CD8+ T cell responses against model antigens and improves protection against infections and tumors.
Science Immunology · Jun 6, 2025Peer-reviewedImmunology