Author

Elisa Cruz-Morales

University of PennsylvaniaORCID 0000-0003-4902-4372Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:multiome· 1

Frequent Co-Authors

Anthony T. PhaniD· 2 shared Christopher A. HunteriD· 2 shared David A. ChristianiD· 2 shared Drew WeissmaniD· 2 shared Emily A. AuninsiD· 2 shared Garima DwivediiD· 2 shared Mohamad‐Gabriel AlamehiD· 2 shared Molly E. BunkofskeiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Anthony T. PhanORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

An IL-12 mRNA-LNP adjuvant enhances mRNA vaccine induced CD8+ T cell responses

Emily A. Aunins, Anthony T. Phan, Mohamad‐Gabriel Alameh, Garima Dwivedi, Elisa Cruz-Morales, David A. Christian, Ying K. Tam, Molly E. Bunkofske, Anabel Zabala-Peñafiel, Keenan M. O’Dea, Maria I. Merolle, Colleen Furey, Phillip Scott, Robert H. Vonderheide, Scott E. Hensley, , Christopher A. Hunter

This study shows that adding IL-12 mRNA-LNPs to an mRNA vaccine enhances CD8+ T cell responses against model antigens and improves protection against infections and tumors.

Science Immunology · Jun 6, 2025Peer-reviewedImmunology

The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8+ T cell responses

Anthony T. Phan, Emily Aunins, Elisa Cruz-Morales, Garima Dwivedi, Molly E. Bunkofske, Julia N. Eberhard, Daniel L. Aldridge, Hooda Said, Omar Banda, Ying K. Tam, David A. Christian, Robert H. Vonderheide, Ross M. Kedl, Drew Weissman, Mohamad‐Gabriel Alameh, Christopher A. Hunter

This study shows that IL-27, induced by mRNA-LNP vaccines, enhances CD8+ T cell responses through type I IFN signaling, improving vaccine efficacy against pathogens and tumors.

bioRxiv · Jan 16, 2025 · PreprintImmunology